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PDYN (prodynorphin)

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Genetics
MOCA Topic Authors: 
Naruya Saitou

PDYN, or prodynorphin, is an endogenous opioid precursor.  This molecule is considered to have critical roles in regulating perception, behavior, and memory.  Promoter region of this gene was shown to be under balancing selection in human populations.  Five polymorphisms within the 5' flanking region that affect transcript abundance were found.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
PDYN (PDYN: prodynorphin)
Type of Human-Specific Changes:
Polymorphism
Related MOCA Topics
References: 

Rockman MV, Hahn MW, Soranzo N, Zimprich F, Goldstein DB, et al. (2005) Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biol 3(12): e387.

 

Babbitt CC, Silverman JS, Haygood R, Reininga JM, Rockman MV, Wray GA. (2010) Multiple Functional Variants in cis Modulate PDYN Expression. Mol. Biol. Evol. 27(2): 465-479.