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SIGLEC

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Gene Family Expansion and Loss
MOCA Topic Authors: 
Veronica Searles
James Sikela

SIGLECs are transmembrane cell surface receptors of the immunoglobulin superfamily that recognize and bind sialic acid. Humans have a number of unique changes in these genes, the nature of which vary among the 13 different gene versions. Changes include increased SIGLEC ligand density, gene loss, gene pseudogenization and novel protein production as a result of gene conversion.

Related MOCA Topics
Related Topics:
TitleCertainty
Gene ConversionLikely
SIGLEC1 (sialic acid binding Ig-like lectin 1, sialoadhesin)True
SIGLEC5 (sialic acid binding Ig-like lectin 5 )True
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Possible Appearance: 
2000 Thousand Years
Definite Appearance: 
100 Thousand Years
The Human Difference: 

Novel gene
Unique expression patterns
Gene deletion
Gene conversion
Amino acid sequence changes

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