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SIGLEC1 (sialic acid binding Ig-like lectin 1, sialoadhesin)

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Ajit Varki

Siglec-1/Sialoadhesin is a conserved sialic acid recognizing protein that is expressed in subsets of rodent and primate macrophages. As it does not bind well to the non-human sialic acid Neu5Gc, humans have an increased density of ligands for this molecule. Human Sialoadhesin show enhanced expression and a wider distribution in splenic macrophages. Further studies are needed to ascertain if this is due to changes in the promoter region of this gene or due to other changes. 

 

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
SIGLEC1 (SIGLEC1: sialic acid binding Ig-like lectin 1, sialoadhesin)
Type of Human-Specific Changes:
Expression Pattern Change
Related MOCA Topics
Related Topics:
TitleCertainty
N-Glycolylneuraminic Acid Expression Speculative
Sialoadhesin on Macrophages True
Referenced By:
TitleCertainty
Absolute Neutrophil CountSpeculative
Sialic Acid-expressing PathogensLikely
SIGLEC True
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Definite Appearance: 
100 Thousand Years