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ZNF322 (Zinc finger protein 322)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

Zink Finger protein 322B (ZNF322B) is a transcriptional activator that may act as a positive regulator of transcription mediated by the MAPK signaling pathway. ZNF322B has 1-3 more copies in the human genome than in any other primate, although the significance of these copies is unknown.

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol:
ZNF322B (ZNF322B: zinc finger protein 322B)
Type of Human-Specific Changes:
Copy Number Changes
Related MOCA Topics
Referenced By:
TitleCertainty
Kruppel-type Zinc Finger FamilyTrue
Timing

Timing of Appearance of the Difference in the Hominin Lineage.

For this entry assume that

  • the common ancestor of humans and old world monkeys was 25000 thousand (25 million) years ago
  • the common ancestor of humans and chimpanzees was 6000 thousand (6 million) years ago
  • the emergence of the genus Homo was 2000 thousand (2 million) years ago
  • the common ancestor of modern humans was 100 thousand years ago

 

Probable Appearance: 
2000 Thousand Years
Definite Appearance: 
6000 Thousand Years
References: 

Itan Y, Bryson K, Thomas MG. (2010) Detecting gene duplications in the human lineage. Ann Hum Genet. 74(6):555-65. PMID: 20946257



Sudmant PH, Kitzman JO, Antonacci F, Alkan C, Malig M, Tsalenko A, Sampas N, Bruhn L, Shendure J; 1000 Genomes Project, Eichler EE. Diversity of human copy number variation and multicopy genes. Science. 2010 Oct 29;330(6004):641-6. PMID:21030649

 

Li Y, Wang Y, Zhang C, Yuan W, Wang J, Zhu C, Chen L, Huang W, Zeng W, Wu X, Liu M. ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1383-92. PMID: 15555580

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