Genome

Genomic structure in Europeans dating back at least 36,200 years.

Seguin-Orlando, A, Korneliussen, TS, Sikora, M, Malaspinas, A, Manica, A, Moltke, I, Albrechtsen, A, Ko, A, Margaryan, A, Moiseyev, V, Goebel, T, Westaway, M, Lambert, D, Khartanovich, V, Wall, JD, Nigst, PR, Foley, RA, Lahr, MMirazón, Nielsen, R, Orlando, L, Willerslev, E. Genomic structure in Europeans dating back at least 36,200 years. Science. 2014;346(6213):1113-8.

Genome-wide ancestry patterns in Rapanui suggest pre-European admixture with Native Americans.

J Moreno-Mayar, V, Rasmussen, S, Seguin-Orlando, A, Rasmussen, M, Liang, M, Flåm, STennebø, Lie, BAlexandra, Gilfillan, GDuncan, Nielsen, R, Thorsby, E, Willerslev, E, Malaspinas, A. Genome-wide ancestry patterns in Rapanui suggest pre-European admixture with Native Americans. Curr Biol. 2014;24(21):2518-25.

Ancient human genomes suggest three ancestral populations for present-day Europeans

Lazaridis, I, Patterson, N, Mittnik, A, Renaud, G, Mallick, S, Kirsanow, K, Sudmant, P, Schraiber, J, Castellano, S, Lipson, M, Berger, B, Economou, C, Bollongino, R, Fu, Q, Bos, KI, Nordenfelt, S, Li, H, de Filippo, C, Prufer, K, Sawyer, S, Posth, C, Haak, W, Hallgren, F, Fornander, E, Rohland, N. Ancient human genomes suggest three ancestral populations for present-day Europeans. Nature. 2014;513:409-413.

Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.

Carneiro, M, Rubin, C, Di Palma, F, Albert, FW, Alföldi, J, Barrio, AMartinez, Pielberg, G, Rafati, N, Sayyab, S, Turner-Maier, J, Younis, S, Afonso, S, Aken, B, Alves, JM, Barrell, D, Bolet, G, Boucher, S, Burbano, HA, Campos, R, Chang, JL, Duranthon, V, Fontanesi, L, Garreau, H, Heiman, D, Johnson, J, Mage, RG, Peng, Z, Queney, G, Rogel-Gaillard, C, Ruffier, M, et al. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication. Science. 2014;345(6200):1074-9.

The genetic prehistory of the New World Arctic.

Raghavan, M, DeGiorgio, M, Albrechtsen, A, Moltke, I, Skoglund, P, Korneliussen, TS, Grønnow, B, Appelt, M, Gulløv, HChristian, T Friesen, M, Fitzhugh, W, Malmström, H, Rasmussen, S, Olsen, J, Melchior, L, Fuller, BT, Fahrni, SM, Stafford, T, Grimes, V, Renouf, MAPriscill, Cybulski, J, Lynnerup, N, Lahr, MMirazón, Britton, K, Knecht, R, Arneborg, J, Metspalu, M, Cornejo, OE, Malaspinas, A, Wang, Y, et al. The genetic prehistory of the New World Arctic. Science. 2014;345(6200):1255832.

8.2% of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineage.

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