@article {12990,
	title = {Intra- and interspecific variation in primate gene expression patterns},
	journal = {Science},
	volume = {296},
	number = {5566},
	year = {2002},
	note = {<p>New York, N.Y.Science. 2002 Apr 12;296(5566):340-3.</p>},
	month = {Apr 12},
	pages = {340-3},
	type = {Comparative StudyResearch Support, Non-U.S. Gov{\textquoteright}t},
	edition = {2002/04/16},
	abstract = {<p>Although humans and their closest evolutionary relatives, the chimpanzees, are 98.7\% identical in their genomic DNA sequences, they differ in many morphological, behavioral, and cognitive aspects. The underlying genetic basis of many of these differences may be altered gene expression. We have compared the transcriptome in blood leukocytes, liver, and brain of humans, chimpanzees, orangutans, and macaques using microarrays, as well as protein expression patterns of humans and chimpanzees using two-dimensional gel electrophoresis. We also studied three mouse species that are approximately as related to each other as are humans, chimpanzees, and orangutans. We identified species-specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.</p>},
	keywords = {*Gene Expression, Animals, Biological Evolution, Brain/*metabolism, Complementary, DNA, Female, Gene Expression Profiling, Haplorhini/*genetics, Hominidae/genetics, Humans, Leukocytes/*metabolism, Liver/*metabolism, Macaca mulatta/genetics, Male, Mice, Mu},
	isbn = {1095-9203 (Electronic)00},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/11951044},
	author = {Enard, W. and Khaitovich, P. and Klose, J. and Zollner, S. and Heissig, F. and Giavalisco, P. and Nieselt-Struwe, K. and Muchmore, E. and Ajit Varki and Ravid, R. and Doxiadis, G. M. and Bontrop, R. E. and Paabo, S.}
}
