@article {153059,
	title = {Effect of adrenocorticotrophic hormone on sodium appetite in mice.},
	journal = {Am J Physiol Regul Integr Comp Physiol},
	volume = {277},
	number = {4 Pt 2},
	year = {1999},
	note = {<p>Am J Physiol. 1999 Oct;277(4 Pt 2):R1033-40.</p>},
	month = {Oct},
	pages = {R1033-40},
	publisher = {UNITED STATES},
	abstract = {<p>A main vector of the effects of stress is secretion of corticotrophin releasing factor (CRF), adrenocorticotrophin (ACTH), and adrenal steroids. Systemic administration of ACTH (2.8 microgram/day sc) for 7 days in BALB/c mice caused a very large increase of voluntary intake of 0.3 M NaCl equivalent to turnover of total body sodium content each day. Intracerebroventricular infusion of ACTH (20 ng/day) had no effect. Intracerebroventricular infusion of ovine CRF (10 ng/h for 7 days) caused an increase of sodium intake. The large sodium appetite-stimulating effect of systemic ACTH was not influenced by concurrent systemic infusion of captopril (2 mg/day). Induction of stress by immobilization of mice on a running wheel caused an increase in Na appetite associated with a 50\% decrease of thymus weight, indicative of corticosteroid effects. The present data suggest that stress and the hormone cascade initiated by stress evoke a large sodium appetite in mice, which may be an important survival mechanism in environmental conditions causing stress.</p>},
	keywords = {Adrenocorticotropic Hormone/blood/pharmacology/*physiology, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Animals, Appetite/drug effects/*physiology, Captopril/pharmacology, Corticotropin-Releasing Hormone/pharmacology, Cosyntropin/pharmacology},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/10516242},
	author = {Denton, DA and Blair West JR and McBurnie, MI and Miller, JA and Weisinger, RS and Williams, RM}
}
