@article {156070,
	title = {The microbiome as a target for endocrine disruptors: Novel chemicals may disrupt androgen and microbiome-mediated autoimmunity},
	journal = {Endocrine Disruptors},
	number = {1},
	year = {2014},
	month = {12/2014},
	pages = {e964539},
	abstract = {<p>In non-obese diabetic (NOD) mice, there is a sex-biased increase in female incidence of type 1 diabetes. Recently, the microbiome was found to protect male mice from type 1 diabetes. Transfer of microbiota from adult NOD male mice to pre-pubertal female mice protects against later incidence of sex-biased type 1 diabetes. This protection involves, in part, microbiome-mediated increased tes- tosterone synthesis, which up-regulates the interleukin and interferon pathways. The microbiome-derived signals that mediate this response are unknown, although due to the diversity of chemicals synthesized in the microbiome some are likely to have structures unlike andro- gens. This suggests that novel synthetic and/or plant-derived chemicals may affect sex-biased autoimmune diseases through disruption of protective signal- ing networks between the microbiome and its host.</p>},
	url = {http://www.tandfonline.com/doi/pdf/10.4161/23273739.2014.964539 },
	author = {Baker, M.E.}
}
