@article {158188,
	title = {Siglec receptors impact mammalian lifespan by modulating oxidative stress.},
	journal = {Elife},
	volume = {4},
	year = {2015},
	abstract = {<p>Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals. In keeping with this, we show that mice lacking Siglec-E, the main member of the CD33rSiglec family, exhibit reduced survival. Removal of Siglec-E causes the development of exaggerated signs of aging at the molecular, structural, and cognitive level. We found that accelerated aging was related both to an unbalanced ROS metabolism, and to a secondary impairment in detoxification of reactive molecules, ultimately leading to increased damage to cellular DNA, proteins, and lipids. Taken together, our data suggest that CD33rSiglecs co-evolved in mammals to achieve a better management of oxidative stress during inflammation, which in turn reduces molecular damage and extends lifespan.</p>
},
	isbn = {2050-084X},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25846707},
	author = {Schwarz, F and Pearce, OM and Wang, X and Samraj, AN and Laubli, H and Garcia, JO and Lin, H and Fu, X and Garcia-Bingman, A and Secrest, P and Romanoski, CE and Heyser, C and Glass, CK and Hazen, SL and Nissi M Varki and Ajit Varki and Gagneux, P}
}
