@article {20390, title = {Developmental Changes in the Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA Transcripts}, journal = {Cereb Cortex}, year = {2013}, note = {

Cereb Cortex.\ 2013 Feb 1. [Epub ahead of print]

}, month = {Feb 1}, edition = {2013/02/05}, abstract = {

The human neocortex is characterized by protracted developmental intervals of synaptogenesis and myelination, which allow for an extended period of learning. The molecular basis of these and other postnatal developmental changes in the human cerebral cortex remain incompletely understood. Recently, a new large class of mammalian genes, encoding nonmessenger, long nonprotein-coding ribonucleic acid (lncRNA) molecules has been discovered. Although their function remains uncertain, numerous lncRNAs have primate-specific sequences and/or show evidence of rapid, lineage-specific evolution, making them potentially relevant to the evolution of unique human neural properties. To examine the hypothesis that lncRNA expression varies with age, potentially paralleling known developmental trends in synaptogenesis, myelination, and energetics, we quantified levels of nearly 6000 lncRNAs in 36 surgically resected human neocortical samples (primarily derived from temporal cortex) spanning infancy to adulthood. Our analysis identified 8 lncRNA genes with distinct developmental expression patterns. These lncRNA genes contained anthropoid-specific exons, as well as splice sites and polyadenylation signals that resided in primate-specific sequences. To our knowledge, our study is the first to describe developmental expression profiles of lncRNA in surgically resected in vivo human brain tissue. Future analysis of the functional relevance of these transcripts to neural development and energy metabolism is warranted.

}, isbn = {1460-2199 (Electronic)10}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23377288}, author = {Lipovich, L and Tarca, AL and Cai, J and Jia, H and Chugani, HT and Sterner, KN and Grossman, LI and Uddin, M and Hof, PR and Sherwood, CC and Kuzawa, CW and Goodman, M and Wildman, DE} }