@article {22139,
	title = {Great ape genetic diversity and population history},
	journal = {Nature},
	volume = {499},
	number = {7459},
	year = {2013},
	note = {<p>Nature. 2013 Jul 25;499(7459):471-5. doi: 10.1038/nature12228. Epub 2013 Jul 3.</p>
},
	month = {Jul 25},
	pages = {471-5},
	type = {Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tResearch Support, U.S. Gov{\textquoteright}t, Non-P.H.S.},
	edition = {2013/07/05},
	abstract = {<p>Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations.</p>
},
	isbn = {1476-4687 (Electronic)00},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23823723},
	author = {Prado-Martinez, J and Sudmant, PH and Kidd, JM and Li, H and Kelley, JL and Lorente-Galdos, B and Veeramah, KR and Woerner, AE and O{\textquoteright}Connor, TD and Santpere, G and Cagan, A and Theunert, C and Casals, F and Laayouni, H and Munch, K and Hobolth, A and Halager, AE and Malig, M and Hernandez-Rodriguez, J and Hernando-Herraez, I and Pr{\"u}fer, K and Pybus, M and Johnstone, L and Lachmann, M and Alkan, C and Twigg, D and Petit, N and Baker, C and Hormozdiari, F and Fern{\'a}ndez-Callejo, M and Dabad, M and Wilson, ML and Stevison, L and Camprubi, C and Carvalho, T and Ruiz-Herrera, A and Vives, L and Mel{\'e}, M and Abell{\'o}, T and Kondova, I and Bontrop, RE and Pusey, A and Lankester, F and Kiyang, JA and Bergl, RA and Lonsdorf, E and Myers, S and Ventura, M and Gagneux, P and Comas, D and Siegismund, H and Blanc, J and Agueda-Calpena, L and Gut, M and Fulton, L and Tishkoff, SA and Mullikin, JC and Wilson, RK and Gut, IG and Gonder, MK and Ryder, OA and Hahn, BH and Navarro, A and Akey, JM and Bertranpetit, J and Reich, D and Mailund, T and Schierup, MH and Hvilsom, C and Andres, AM and Wall, JD and Bustamante, CD and Hammer, MF and Eichler, EE and Marqu{\`e}s-Bonet, T}
}
