@article {24125,
	title = {Global epigenomic reconfiguration during mammalian brain development},
	journal = {Science},
	volume = {341},
	number = {6146},
	year = {2013},
	note = {<p>Science. 2013 Aug 9;341(6146):1237905. doi: 10.1126/science.1237905. Epub 2013 Jul 4.</p>
},
	month = {Aug 9},
	pages = {1237905},
	type = {Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov{\textquoteright}tResearch Support, U.S. Gov{\textquoteright}t, Non-P.H.S.},
	edition = {2013/07/06},
	abstract = {<p>DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.</p>
},
	keywords = {\&, *DNA Methylation, *Epigenesis, *Gene Expression Regulation, 5-Methylcytosine/metabolism, Adult, Animals, Base Sequence, Conserved Sequence, Cytosine/*analogs, derivatives/metabolism, Devel, development, Epigenomics, Frontal Lobe/*growth, Genetic},
	isbn = {1095-9203 (Electronic)00},
	url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/},
	author = {Lister, R. and Mukamel, E. A. and Nery, J. R. and Urich, M. and Puddifoot, C. A. and Johnson, N. D. and Lucero, J. and Huang, Y. and Dwork, A. J. and Schultz, M. D. and Yu, M. and Tonti-Filippini, J. and Heyn, H. and Hu, S. and Wu, J. C. and Rao, A. and Esteller, M. and He, C. and Haghighi, F. G. and Sejnowski, T. J. and Behrens, M. M. and Ecker, J. R.}
}
