@article {308311,
	title = {Gut Microbiome of Coexisting BaAka Pygmies and Bantu Reflects Gradients of Traditional Subsistence Patterns.},
	journal = {Cell Rep},
	volume = {14},
	year = {2016},
	note = {http://www.sciencedirect.com/science/article/pii/S2211124716300997},
	month = {2016 Mar 8},
	pages = {2142-53},
	abstract = {<p>To understand how the gut microbiome is impacted by human adaptation to varying environments, we explored gut bacterial communities in the BaAka rainforest hunter-gatherers and their agriculturalist Bantu neighbors in the Central African Republic. Although the microbiome of both groups is compositionally similar, hunter-gatherers harbor increased abundance of Prevotellaceae, Treponema, and Clostridiaceae, while the Bantu gut microbiome is dominated by Firmicutes. Comparisons with US Americans reveal microbiome differences between Africans and westerners but show western-like features in the Bantu, including an increased abundance of predictive carbohydrate and xenobiotic metabolic pathways. In contrast, the hunter-gatherer gut shows increased abundance of predicted virulence, amino acid, and vitamin metabolism functions, as well as dominance of lipid and amino-acid-derived metabolites, as determined through metabolomics. Our results demonstrate gradients of traditional subsistence patterns in two neighboring African groups and highlight the adaptability of the microbiome in response to host ecology.</p>},
	issn = {2211-1247},
	doi = {10.1016/j.celrep.2016.02.013},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/26923597},
	author = {Gomez, Andres and Petrzelkova, Klara J and Burns, Michael B and Yeoman, Carl J and Amato, Katherine R and Vlckova, Klara and Modry, David and Todd, Angelique and Jost Robinson, Carolyn A and Remis, Melissa J and Torralba, Manolito G and Morton, Elise and Uma{\~n}a, Juan D and Carbonero, Franck and Gaskins, H Rex and Nelson, Karen E and Wilson, Brenda A and Stumpf, Rebecca M and White, Bryan A and Leigh, Steven R and Blekhman, Ran}
}
