@article {308396,
	title = {Eight thousand years of natural selection in Europe},
	year = {2015},
	abstract = {<p><span style="color: rgb(25, 25, 25); font-family: {\textquoteright}Lucida Sans{\textquoteright}, Helvetica, Arial, sans-serif; font-size: 14.6667px; line-height: 27.28px;">The arrival of farming in Europe around 8,500 years ago necessitated adaptation to new environments, pathogens, diets, and social organizations. While indirect evidence of adaptation can be detected in patterns of genetic variation in present-day people, ancient DNA makes it possible to witness selection directly by analyzing samples from populations before, during and after adaptation events. Here we report the first genome-wide scan for selection using ancient DNA, capitalizing on the largest genome-wide dataset yet assembled: 230 West Eurasians dating to between 6500 and 1000 BCE, including 163 with newly reported data. The new samples include the first genome-wide data from the Anatolian Neolithic culture, who we show were members of the population that was the source of Europe{\textquoteright}s first farmers, and whose genetic material we extracted by focusing on the DNA-rich petrous bone. We identify genome-wide significant signatures of selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.</span></p>
},
	url = {http://biorxiv.org/content/early/2015/10/10/016477},
	author = {Mathieson, I. and Lazaridis, I. and Rohland, N. and Mallick, S. and Patterson, N. and Alpaslan, S. and Roodenberg, E. and Harney, K. and Stewardson, K. and Fernandes, D. and Novak, M. and Sirak, K. and Gamba, C. and Jones, E. and Llamas, B. and Dryomov, S. and Pickrell, J. and Arsuaga, J. and de Castro, J. and Carbonell, E. and Gerritsen, F. and Khokhlov, A. and Kuznetsov, P. and Lozano, M. and Meller, H. and Mochalov, O. and Moiseyev, V. and Guerra, M. and Roodenberg, J. and Verges, J. and Krause, J. and Cooper, A. and Alt, K. and Brown, D. and Anthony, D. and Lalueza-Fox, C. and Haak, W. and Pinhasi, R. and Reich, D.}
}
