@article {308420,
	title = {Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania.},
	journal = {Am J Hum Genet},
	volume = {89},
	year = {2011},
	note = {<p>http://www.sciencedirect.com/science/article/pii/S0002929711003958</p>
},
	month = {2011 Oct 7},
	pages = {516-28},
	abstract = {<p>It has recently been shown that ancestors of New Guineans and Bougainville Islanders have inherited a proportion of their ancestry from Denisovans, an archaic hominin group from Siberia. However, only a sparse sampling of populations from Southeast Asia and Oceania were analyzed. Here, we quantify Denisova admixture in 33 additional populations from Asia and Oceania. Aboriginal Australians, Near Oceanians, Polynesians, Fijians, east Indonesians, and Mamanwa (a "Negrito" group from the Philippines) have all inherited genetic material from Denisovans, but mainland East Asians, western Indonesians, Jehai (a Negrito group from Malaysia), and Onge (a Negrito group from the Andaman Islands) have not. These results indicate that Denisova gene flow occurred into the common ancestors of New Guineans, Australians, and Mamanwa but not into the ancestors of the Jehai and Onge and suggest that relatives of present-day East Asians were not in Southeast Asia when the Denisova gene flow occurred. Our finding that descendants of the earliest inhabitants of Southeast Asia do not all harbor Denisova admixture is inconsistent with a history in which the Denisova interbreeding occurred in mainland Asia and then spread over Southeast Asia, leading to all its earliest modern human inhabitants. Instead, the data can be most parsimoniously explained if the Denisova gene flow occurred in Southeast Asia itself. Thus, archaic Denisovans must have lived over an extraordinarily broad geographic and ecological range, from Siberia to tropical Asia.</p>
},
	keywords = {Animals, Asia, Southeastern, Biological Evolution, DNA, Mitochondrial, Gene Flow, Genotype, Geography, Hominidae, Humans, Models, Genetic, Models, Statistical, Oceania, Oceanic Ancestry Group, Pan troglodytes, Polymorphism, Single Nucleotide},
	issn = {1537-6605},
	doi = {10.1016/j.ajhg.2011.09.005},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/21944045},
	author = {Reich, David and Patterson, Nick and Kircher, Martin and Delfin, Frederick and Nandineni, Madhusudan R and Pugach, Irina and Ko, Albert Min-Shan and Ko, Ying-Chin and Jinam, Timothy A and Phipps, Maude E and Saitou, Naruya and Wollstein, Andreas and Kayser, Manfred and P{\"a}{\"a}bo, Svante and Stoneking, Mark}
}
