@article {308500,
	title = {Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians.},
	journal = {Am J Hum Genet},
	volume = {96},
	year = {2015},
	note = {http://www.sciencedirect.com/science/article/pii/S0002929715001561},
	month = {2015 Jun 4},
	pages = {986-91},
	abstract = {<p>The predominantly African origin of all modern human populations is well established, but the route taken out of Africa is still unclear. Two alternative routes, via Egypt and Sinai or across the Bab el Mandeb strait into Arabia, have traditionally been proposed as feasible gateways in light of geographic, paleoclimatic, archaeological, and genetic evidence. Distinguishing among these alternatives has been difficult. We generated 225 whole-genome sequences (225 at 8{\texttimes} depth, of which 8 were increased to 30{\texttimes}; Illumina HiSeq 2000) from six modern Northeast African populations (100 Egyptians and five Ethiopian populations each represented by 25 individuals). West Eurasian components were masked out, and the remaining African haplotypes were compared with a panel of sub-Saharan African and non-African genomes. We showed that masked Northeast African haplotypes overall were more similar to non-African haplotypes and more frequently present outside Africa than were any sets of haplotypes derived from a West African population. Furthermore, the masked Egyptian haplotypes showed these properties more markedly than the masked Ethiopian haplotypes, pointing to Egypt as the more likely gateway in the exodus to the rest of the world. Using five Ethiopian and three Egyptian high-coverage masked genomes and the multiple sequentially Markovian coalescent (MSMC) approach, we estimated the genetic split times of Egyptians and Ethiopians from non-African populations at 55,000 and 65,000 years ago, respectively, whereas that of West Africans was estimated to be 75,000 years ago. Both the haplotype and MSMC analyses thus suggest a predominant northern route out of Africa via Egypt.</p>},
	keywords = {African Continental Ancestry Group, Base Sequence, Biological Evolution, Egypt, Ethiopia, Genome, Human, Geography, Haplotypes, High-Throughput Nucleotide Sequencing, History, Ancient, Human Migration, Humans, Markov Chains, Models, Genetic, Molecular Sequence Data, Principal Component Analysis},
	issn = {1537-6605},
	doi = {10.1016/j.ajhg.2015.04.019},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/26027499},
	author = {Pagani, Luca and Schiffels, Stephan and Gurdasani, Deepti and Danecek, Petr and Scally, Aylwyn and Chen, Yuan and Xue, Yali and Haber, Marc and Ekong, Rosemary and Oljira, Tamiru and Mekonnen, Ephrem and Luiselli, Donata and Bradman, Neil and Bekele, Endashaw and Zalloua, Pierre and Durbin, Richard and Kivisild, Toomas and Tyler-Smith, Chris}
}
