@article {308626,
	title = {Identification of a spinal circuit for light touch and fine motor control.},
	journal = {Cell},
	volume = {160},
	year = {2015},
	note = {http://www.sciencedirect.com/science/article/pii/S0092867415000124},
	month = {2015 Jan 29},
	pages = {503-15},
	abstract = {<p>Sensory circuits in the dorsal spinal cord integrate and transmit multiple cutaneous sensory modalities including the sense of light touch. Here, we identify a population of excitatory interneurons (INs) in the dorsal horn that are important for transmitting innocuous light touch sensation. These neurons express the ROR alpha (RORα) nuclear orphan receptor and are selectively innervated by cutaneous low threshold mechanoreceptors (LTMs). Targeted removal of RORα INs in the dorsal spinal cord leads to a marked reduction in behavioral responsiveness to light touch without affecting responses to noxious and itch stimuli. RORα IN-deficient mice also display a selective deficit in corrective foot movements. This phenotype, together with our demonstration that the RORα INs are innervated by corticospinal and vestibulospinal projection neurons, argues that the RORα INs direct corrective reflex movements by integrating touch information with descending motor commands from the cortex and cerebellum.</p>},
	keywords = {Animals, Interneurons, Mechanotransduction, Cellular, Mice, Motor Activity, Motor Neurons, Neural Pathways, Nuclear Receptor Subfamily 1, Group F, Member 1, Spinal Cord Dorsal Horn, Synapses, Touch},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2015.01.011},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25635458},
	author = {Bourane, Steeve and Grossmann, Katja S and Britz, Olivier and Dalet, Antoine and Del Barrio, Marta Garcia and Stam, Floor J and Garcia-Campmany, Lidia and Koch, Stephanie and Goulding, Martyn}
}
