@article {308672,
	title = {Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.},
	journal = {Science},
	volume = {347},
	year = {2015},
	note = {http://www.sciencemag.org/content/early/2014/12/03/science.1262092.full},
	month = {2015 Jan 2},
	pages = {81-3},
	abstract = {<p>Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95\% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95\% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95\% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.</p>},
	keywords = {Aged, Aged, 80 and over, Blood Cells, Chromosomes, Human, Y, Cohort Studies, Female, Humans, Incidence, Lung Neoplasms, Male, Middle Aged, Mutagenesis, Risk Factors, Sex Factors, Smoking, Sweden},
	issn = {1095-9203},
	doi = {10.1126/science.1262092},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25477213},
	author = {Dumanski, Jan P and Rasi, Chiara and L{\"o}nn, Mikael and Davies, Hanna and Ingelsson, Martin and Giedraitis, Vilmantas and Lannfelt, Lars and Magnusson, Patrik K E and Lindgren, Cecilia M and Morris, Andrew P and Cesarini, David and Johannesson, Magnus and Tiensuu Janson, Eva and Lind, Lars and Pedersen, Nancy L and Ingelsson, Erik and Forsberg, Lars A}
}
