@article {308673,
	title = {Khoisan hunter-gatherers have been the largest population throughout most of modern-human demographic history.},
	journal = {Nat Commun},
	volume = {5},
	year = {2014},
	note = {http://www.nature.com/ncomms/2014/141204/ncomms6692/full/ncomms6692.html},
	month = {2014},
	pages = {5692},
	abstract = {<p>The Khoisan people from Southern Africa maintained ancient lifestyles as hunter-gatherers or pastoralists up to modern times, though little else is known about their early history. Here we infer early demographic histories of modern humans using whole-genome sequences of five Khoisan individuals and one Bantu speaker. Comparison with a 420 K SNP data set from worldwide individuals demonstrates that two of the Khoisan genomes from the Ju/{\textquoteright}hoansi population contain exclusive Khoisan ancestry. Coalescent analysis shows that the Khoisan and their ancestors have been the largest populations since their split with the non-Khoisan population ~100-150 kyr ago. In contrast, the ancestors of the non-Khoisan groups, including Bantu-speakers and non-Africans, experienced population declines after the split and lost more than half of their genetic diversity. Paleoclimate records indicate that the precipitation in southern Africa increased ~80-100 kyr ago while west-central Africa became drier. We hypothesize that these climate differences might be related to the divergent-ancient histories among human populations.</p>},
	keywords = {Africa, Southern, African Continental Ancestry Group, Demography, Female, Genetic Variation, Genetics, Population, Humans, Male, Sequence Analysis, DNA},
	issn = {2041-1723},
	doi = {10.1038/ncomms6692},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25471224},
	author = {Kim, Hie Lim and Ratan, Aakrosh and Perry, George H and Montenegro, Alvaro and Miller, Webb and Schuster, Stephan C}
}
