@article {308678,
	title = {The African Genome Variation Project shapes medical genetics in Africa.},
	journal = {Nature},
	volume = {517},
	year = {2015},
	note = {http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13997.html},
	month = {2015 Jan 15},
	pages = {327-32},
	abstract = {<p>Given the importance of Africa to studies of human origins and disease susceptibility, detailed characterization of African genetic diversity is needed. The African Genome Variation Project provides a resource with which to design, implement and interpret genomic studies in sub-Saharan Africa and worldwide. The African Genome Variation Project represents dense genotypes from 1,481 individuals and whole-genome sequences from 320 individuals across sub-Saharan Africa. Using this resource, we find novel evidence of complex, regionally distinct hunter-gatherer and Eurasian admixture across sub-Saharan Africa. We identify new loci under selection, including loci related to malaria susceptibility and hypertension. We show that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa. Using whole-genome sequencing, we demonstrate further improvements in imputation accuracy, strengthening the case for large-scale sequencing efforts of diverse African haplotypes. Finally, we present an efficient genotype array design capturing common genetic variation in Africa.</p>},
	keywords = {Africa, Africa South of the Sahara, Asia, Europe, Genetic Variation, Genetics, Medical, Genome, Human, Genomics, Humans, Risk Factors, Selection, Genetic},
	issn = {1476-4687},
	doi = {10.1038/nature13997},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25470054},
	author = {Gurdasani, Deepti and Carstensen, Tommy and Tekola-Ayele, Fasil and Pagani, Luca and Tachmazidou, Ioanna and Hatzikotoulas, Konstantinos and Karthikeyan, Savita and Iles, Louise and Pollard, Martin O and Choudhury, Ananyo and Ritchie, Graham R S and Xue, Yali and Asimit, Jennifer and Nsubuga, Rebecca N and Young, Elizabeth H and Pomilla, Cristina and Kivinen, Katja and Rockett, Kirk and Kamali, Anatoli and Doumatey, Ayo P and Asiki, Gershim and Seeley, Janet and Sisay-Joof, Fatoumatta and Jallow, Muminatou and Tollman, Stephen and Mekonnen, Ephrem and Ekong, Rosemary and Oljira, Tamiru and Bradman, Neil and Bojang, Kalifa and Ramsay, Michele and Adeyemo, Adebowale and Bekele, Endashaw and Motala, Ayesha and Norris, Shane A and Pirie, Fraser and Kaleebu, Pontiano and Kwiatkowski, Dominic and Tyler-Smith, Chris and Rotimi, Charles and Zeggini, Eleftheria and Sandhu, Manjinder S}
}
