@article {308699, title = {Genome-wide scan demonstrates significant linkage for male sexual orientation.}, journal = {Psychol Med}, volume = {45}, year = {2015}, note = {http://journals.cambridge.org/action/displayFulltext?type=6\&fid=9385647\&jid=PSM\&volumeId=-1\&issueId=-1\&aid=9385646\&bodyId=\&membershipNumber=\&societyETOCSession=\&fulltextType=RA\&fileId=S0033291714002451}, month = {2015 May}, pages = {1379-88}, abstract = {

BACKGROUND: Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.

METHOD: We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.

RESULTS: We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD~=~4.08, maximum multipoint LOD~=~2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD~=~2.99, maximum multipoint LOD~=~2.76), which was also implicated in prior research.

CONCLUSIONS: Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

}, keywords = {Adult, Chromosomes, Human, Pair 8, Chromosomes, Human, X, Genetic Linkage, Genome-Wide Association Study, Homosexuality, Male, Humans, Male, Siblings, United States}, issn = {1469-8978}, doi = {10.1017/S0033291714002451}, url = {http://www.ncbi.nlm.nih.gov/pubmed/25399360}, author = {Sanders, A R and Martin, E R and Beecham, G W and Guo, S and Dawood, K and Rieger, G and Badner, J A and Gershon, E S and Krishnappa, R S and Kolundzija, A B and Duan, J and Gejman, P V and Bailey, J M} }