@article {308710,
	title = {The architecture and evolution of cancer neochromosomes.},
	journal = {Cancer Cell},
	volume = {26},
	year = {2014},
	note = {http://www.sciencedirect.com/science/article/pii/S1535610814003730$\#$},
	month = {2014 Nov 10},
	pages = {653-67},
	abstract = {<p>We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes, which can exceed 600 Mb in size, initially arise as circular structures following chromothripsis involving chromosome 12. The core of the neochromosome is amplified, rearranged, and corroded through hundreds of breakage-fusion-bridge cycles. Under selective pressure, amplified oncogenes are overexpressed, while coamplified passenger genes may be silenced epigenetically. New material may be captured during punctuated chromothriptic events. Centromeric corrosion leads to crisis, which is resolved through neocentromere formation or native centromere capture. Finally, amplification terminates, and the neochromosome core is stabilized in linear form by telomere capture. This study investigates the dynamic mutational processes underlying the life history of a special form of cancer mutation.</p>},
	keywords = {Aged, Carcinogenesis, Cell Line, Tumor, Centromere, Chromosome Aberrations, Chromosomes, Human, Female, Humans, Liposarcoma, Models, Genetic, Mutagenesis, Oncogenes, Retroperitoneal Neoplasms, Translocation, Genetic},
	issn = {1878-3686},
	doi = {10.1016/j.ccell.2014.09.010},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25517748},
	author = {Garsed, Dale W and Marshall, Owen J and Corbin, Vincent D A and Hsu, Arthur and Di Stefano, Leon and Schr{\"o}der, Jan and Li, Jason and Feng, Zhi-Ping and Kim, Bo W and Kowarsky, Mark and Lansdell, Ben and Brookwell, Ross and Myklebost, Ola and Meza-Zepeda, Leonardo and Holloway, Andrew J and Pedeutour, Florence and Choo, K H Andy and Damore, Michael A and Deans, Andrew J and Papenfuss, Anthony T and Thomas, David M}
}
