@article {308774,
	title = {Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.},
	journal = {PLoS Genet},
	volume = {9},
	year = {2013},
	note = {http://www.plosgenetics.org/article/info\%3Adoi\%2F10.1371\%2Fjournal.pgen.1003751},
	month = {2013},
	pages = {e1003751},
	abstract = {<p>Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study meta-analysis for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)] (n = 728). The most strongly associated variant, rs7182874 (P = 8.68 {\texttimes} 10(-9)), is located in PCSK6, further supporting an association we previously reported. We also confirmed the specificity of this association in individuals with RD; the same locus was not associated with relative hand skill in a general population cohort (n = 2,666). As PCSK6 is known to regulate NODAL in the development of left/right (LR) asymmetry in mice, we developed a novel approach to GWAS pathway analysis, using gene-set enrichment to test for an over-representation of highly associated variants within the orthologs of genes whose disruption in mice yields LR asymmetry phenotypes. Four out of 15 LR asymmetry phenotypes showed an over-representation (FDR <= 5\%). We replicated three of these phenotypes; situs inversus, heterotaxia, and double outlet right ventricle, in the general population cohort (FDR <= 5\%). Our findings lead us to propose that handedness is a polygenic trait controlled in part by the molecular mechanisms that establish LR body asymmetry early in development.</p>},
	keywords = {Animals, Body Patterning, Brain, Dyslexia, Functional Laterality, Genome-Wide Association Study, Humans, Mice, Multifactorial Inheritance, Proprotein Convertases, Serine Endopeptidases},
	issn = {1553-7404},
	doi = {10.1371/journal.pgen.1003751},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24068947},
	author = {Brandler, William M and Morris, Andrew P and Evans, David M and Scerri, Thomas S and Kemp, John P and Timpson, Nicholas J and St Pourcain, Beate and Smith, George Davey and Ring, Susan M and Stein, John and Monaco, Anthony P and Talcott, Joel B and Fisher, Simon E and Webber, Caleb and Paracchini, Silvia}
}
