@article {308779,
	title = {Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.},
	journal = {Science},
	volume = {345},
	year = {2014},
	note = {http://www.sciencemag.org/content/345/6200/1074.full},
	month = {2014 Aug 29},
	pages = {1074-9},
	abstract = {<p>The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.</p>},
	keywords = {Animals, Animals, Domestic, Animals, Wild, Base Sequence, Behavior, Animal, Breeding, Evolution, Molecular, Gene Frequency, Genetic Loci, Genome, Molecular Sequence Data, Phenotype, Polymorphism, Single Nucleotide, Rabbits, Selection, Genetic, Sequence Analysis, DNA},
	issn = {1095-9203},
	doi = {10.1126/science.1253714},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/25170157},
	author = {Carneiro, Miguel and Rubin, Carl-Johan and Di Palma, Federica and Albert, Frank W and Alf{\"o}ldi, Jessica and Barrio, Alvaro Martinez and Pielberg, Gerli and Rafati, Nima and Sayyab, Shumaila and Turner-Maier, Jason and Younis, Shady and Afonso, Sandra and Aken, Bronwen and Alves, Joel M and Barrell, Daniel and Bolet, Gerard and Boucher, Samuel and Burbano, Hern{\'a}n A and Campos, Rita and Chang, Jean L and Duranthon, Veronique and Fontanesi, Luca and Garreau, Herv{\'e} and Heiman, David and Johnson, Jeremy and Mage, Rose G and Peng, Ze and Queney, Guillaume and Rogel-Gaillard, Claire and Ruffier, Magali and Searle, Steve and Villafuerte, Rafael and Xiong, Anqi and Young, Sarah and Forsberg-Nilsson, Karin and Good, Jeffrey M and Lander, Eric S and Ferrand, Nuno and Lindblad-Toh, Kerstin and Andersson, Leif}
}
