@article {308843,
	title = {Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits.},
	journal = {Science},
	volume = {344},
	year = {2014},
	note = {http://www.sciencemag.org/content/344/6189/1280},
	month = {2014 Jun 13},
	pages = {1280-5},
	abstract = {<p>Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic variation within Mexico from over 1000 individuals representing 20 indigenous and 11 mestizo populations. We found striking genetic stratification among indigenous populations within Mexico at varying degrees of geographic isolation. Some groups were as differentiated as Europeans are from East Asians. Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country. Furthermore, two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Thus, accounting for fine-scale ancestry patterns is critical for medical and population genetic studies within Mexico, in Mexican-descent populations, and likely in many other populations worldwide.</p>},
	keywords = {African Continental Ancestry Group, European Continental Ancestry Group, Genetic Variation, Genome, Human, Humans, Indians, North American, Mexican Americans, Mexico, Population},
	issn = {1095-9203},
	doi = {10.1126/science.1251688},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24926019},
	author = {Moreno-Estrada, Andr{\'e}s and Gignoux, Christopher R and Fern{\'a}ndez-L{\'o}pez, Juan Carlos and Zakharia, Fouad and Sikora, Martin and Contreras, Alejandra V and Acu{\~n}a-Alonzo, Victor and Sandoval, Karla and Eng, Celeste and Romero-Hidalgo, Sandra and Ortiz-Tello, Patricia and Robles, Victoria and Kenny, Eimear E and Nu{\~n}o-Arana, Ismael and Barquera-Lozano, Rodrigo and Mac{\'\i}n-P{\'e}rez, Gast{\'o}n and Granados-Arriola, Julio and Huntsman, Scott and Galanter, Joshua M and Via, Marc and Ford, Jean G and Chapela, Roc{\'\i}o and Rodriguez-Cintron, William and Rodr{\'\i}guez-Santana, Jose R and Romieu, Isabelle and Sienra-Monge, Juan Jos{\'e} and del Rio Navarro, Blanca and London, Stephanie J and Ruiz-Linares, Andres and Garcia-Herrera, Rodrigo and Estrada, Karol and Hidalgo-Miranda, Alfredo and Jimenez-Sanchez, Gerardo and Carnevale, Alessandra and Sober{\'o}n, Xavier and Canizales-Quinteros, Samuel and Rangel-Villalobos, H{\'e}ctor and Silva-Zolezzi, Irma and Burchard, Esteban Gonzalez and Bustamante, Carlos D}
}
