@article {309004,
	title = {Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.},
	journal = {Cell},
	volume = {155},
	year = {2013},
	note = {http://www.cell.com/retrieve/pii/S0092867413012968},
	month = {2013 Nov 21},
	pages = {997-1007},
	abstract = {<p>Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology. Recent studies employing exome- and genome-wide sequencing have identified nine high-confidence ASD (hcASD) genes. Working from the hypothesis that ASD-associated mutations in these biologically pleiotropic genes will disrupt intersecting developmental processes to contribute to a common phenotype, we have attempted to identify time periods, brain regions, and cell types in which these genes converge. We have constructed coexpression networks based on the hcASD "seed" genes, leveraging a rich expression data set encompassing multiple human brain regions across human development and into adulthood. By assessing enrichment of an~independent set of probable ASD (pASD) genes, derived from the same sequencing studies, we demonstrate a key point of convergence in midfetal layer 5/6 cortical projection neurons. This approach informs when, where, and in what cell types mutations in these specific genes may be productively studied to clarify ASD pathophysiology.</p>},
	keywords = {Animals, Brain, Child Development Disorders, Pervasive, Exome, Female, Fetus, Gene Expression Profiling, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Mice, Mutation, Neurons, Prefrontal Cortex, Sequence Analysis, DNA},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2013.10.020},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/24267886},
	author = {Willsey, A Jeremy and Sanders, Stephan J and Li, Mingfeng and Dong, Shan and Tebbenkamp, Andrew T and Muhle, Rebecca A and Reilly, Steven K and Lin, Leon and Fertuzinhos, Sofia and Miller, Jeremy A and Murtha, Michael T and Bichsel, Candace and Niu, Wei and Cotney, Justin and Ercan-Sencicek, A Gulhan and Gockley, Jake and Gupta, Abha R and Han, Wenqi and He, Xin and Hoffman, Ellen J and Klei, Lambertus and Lei, Jing and Liu, Wenzhong and Liu, Li and Lu, Cong and Xu, Xuming and Zhu, Ying and Mane, Shrikant M and Lein, Ed S and Wei, Liping and Noonan, James P and Roeder, Kathryn and Devlin, Bernie and Sestan, Nenad and State, Matthew W}
}
