@article {309488,
	title = {Molecular genetic basis of the histo-blood group ABO system.},
	journal = {Nature},
	volume = {345},
	year = {1990},
	month = {1990 May 17},
	pages = {229-33},
	abstract = {<p>The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities converting the H antigen into A or B antigens, whereas O(H) individuals lack such activity. Here we present a molecular basis for the ABO genotypes. The A and B genes differ in a few single-base substitutions, changing four amino-acid residues that may cause differences in A and B transferase specificity. A critical single-base deletion was found in the O gene, which results in an entirely different, inactive protein incapable of modifying the H antigen.</p>
},
	keywords = {ABO Blood-Group System, Alleles, Amino Acid Sequence, Base Sequence, Carbohydrate Sequence, Cell Line, DNA, Gene Library, Genotype, Humans, Molecular Sequence Data, Polymorphism, Genetic},
	issn = {0028-0836},
	doi = {10.1038/345229a0},
	author = {Yamamoto, F and Clausen, H and White, T and Marken, J and Hakomori, S}
}
