@article {309585,
	title = {The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis.},
	journal = {J Lipids},
	volume = {2011},
	year = {2011},
	month = {2011},
	pages = {271062},
	abstract = {<p>Background. Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56-80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination. VLDL particles, Sf 20-400, were isolated and their lipid composition and apoC-I content determined. Results. The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P = 0.048) under fasting conditions. Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P = 0.011). The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (P for trend \&lt;0.001. The amount of apoC-I molecules per VLDL was correlated with the total (r = 0.41, P \&lt; 0.0001) and incremental (r = 0.35, P \&lt; 0.001) area under the postprandial triglyceride curve. Conclusions. Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis.</p>
},
	issn = {2090-3049},
	doi = {10.1155/2011/271062},
	author = {Hansen, John-Bjarne and Fern{\'a}ndez, Jos{\'e} A and Not{\o}, Ann-Trude With and Deguchi, Hiroshi and Bj{\"o}rkegren, Johan and Mathiesen, Ellisiv B}
}
