@article {309640,
	title = {Spindle neurons of the human anterior cingulate cortex.},
	journal = {J Comp Neurol},
	volume = {355},
	year = {1995},
	month = {1995 Apr 24},
	pages = {27-37},
	abstract = {<p>The human anterior cingulate cortex is distinguished by the presence of an unusual cell type, a large spindle neuron in layer Vb. This cell has been noted numerous times in the historical literature but has not been studied with modern neuroanatomic techniques. For instance, details regarding the neuronal class to which these cells belong and regarding their precise distribution along both ventrodorsal and anteroposterior axes of the cingulate gyrus are still lacking. In the present study, morphological features and the anatomic distribution of this cell type were studied using computer-assisted mapping and immunocytochemical techniques. Spindle neurons are restricted to the subfields of the anterior cingulate cortex (Brodmann{\textquoteright}s area 24), exhibiting a greater density in anterior portions of this area than in posterior portions, and tapering off in the transition zone between anterior and posterior cingulate cortex. Furthermore, a majority of the spindle cells at any level is located in subarea 24b on the gyral surface. Immunocytochemical analysis revealed that the neurofilament protein triple was present in a large percentage of these neurons and that they did not contain calcium-binding proteins. Injections of the carbocyanine dye DiI into the cingulum bundle revealed that these cells are projection neurons. Finally, spindle cells were consistently affected in Alzheimer{\textquoteright}s disease cases, with an overall loss of about 60\%. Taken together, these observations indicate that the spindle cells of the human cingulate cortex represent a morphological subpopulation of pyramidal neurons whose restricted distribution may be associated with functionally distinct areas.</p>
},
	keywords = {Aged, Aged, 80 and over, Alzheimer Disease, Brain Mapping, Gyrus Cinguli, Humans, Middle Aged, Pyramidal Cells},
	issn = {0021-9967},
	doi = {10.1002/cne.903550106},
	author = {Nimchinsky, E A and Vogt, B A and Morrison, J H and Hof, P R}
}
