@article {309652,
	title = {Neandertal origin of genetic variation at the cluster of OAS immunity genes},
	journal = {Mol. Bio. Evol. },
	volume = {30},
	year = {2013},
	pages = {798-801},
	abstract = {<p>Analyses of ancient DNA from extinct humans reveal signals of at least two independent hybridization events in the history of non-African populations. To date there are very few examples of specific genetic variants that have been rigorously identified as introgressive. Here we survey DNA sequence variation in the\&nbsp;OAS\&nbsp;gene cluster on chromosome 12 and provide strong evidence that a haplotype extending for ~185 kb introgressed from Neandertals. This haplotype is nearly restricted to Eurasians and is estimated to have diverged from the Neandertal sequence ~125 kya. Despite the potential for novel functional variation, the observed frequency of this haplotype is consistent with neutral introgression. This is the second locus in the human genome, after\&nbsp;STAT2, carrying distinct haplotypes that appear to have introgressed separately from both Neandertals and Denisova.</p>
},
	doi = {10.1093/molbev/mst004},
	author = {Mendez, F. L. and Watkins, J. C. and Hammer, M. F.}
}
