@article {309749,
	title = {Resurrecting surviving Neandertal lineages from modern human genomes.},
	journal = {Science},
	volume = {343},
	year = {2014},
	month = {2014 Feb 28},
	pages = {1017-21},
	abstract = {<p>Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1 to 3\% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering more than 15 gigabases of introgressed sequence that spans ~20\% of the Neandertal genome (false discovery rate = 5\%). Analyses of surviving archaic lineages suggest that there were fitness costs to hybridization, admixture occurred both before and after divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes. Our results provide a new avenue for paleogenomics studies, allowing substantial amounts of population-level DNA sequence information to be obtained from extinct groups, even in the absence of fossilized remains.</p>
},
	keywords = {Animals, Genetic Variation, Genome, Human, Humans, Hybridization, Genetic, Indians, North American, Neanderthals, Sequence Analysis, DNA},
	issn = {1095-9203},
	doi = {10.1126/science.1245938},
	url = {http://science.sciencemag.org/content/343/6174/1017.long},
	author = {Vernot, Benjamin and Akey, Joshua M}
}
