@article {309867,
	title = {The complex structure and dynamic evolution of human subtelomeres.},
	journal = {Nat Rev Genet},
	volume = {3},
	year = {2002},
	month = {2002 Feb},
	pages = {91-102},
	abstract = {<p>Subtelomeres are extraordinarily dynamic and variable regions near the ends of chromosomes. They are defined by their unusual structure: patchworks of blocks that are duplicated near the ends of multiple chromosomes. Duplications among subtelomeres have spawned small gene families, making inter-individual variation in subtelomeres a potential source of phenotypic diversity. The ectopic recombination that occurs between subtelomeres might also have a role in reconstituting telomeres in the absence of telomerase. However, the propensity for subtelomeres to interchange is a double-edged sword, as extensive subtelomeric homology can mediate deleterious rearrangements of the ends of chromosomes to cause human disease.</p>
},
	keywords = {Animals, Biological Evolution, Ethnic groups, Gene Rearrangement, Genetic Diseases, Inborn, Genetic Variation, Humans, In Situ Hybridization, Fluorescence, Models, Genetic, Multigene Family, Polymerase Chain Reaction, Primates, Recombination, Genetic, Telomere},
	issn = {1471-0056},
	doi = {10.1038/nrg727},
	author = {Mefford, Heather C and Trask, Barbara J}
}
