@article {309883,
	title = {Diet-induced systemic lupus erythematosus (SLE) in primates.},
	journal = {Am J Kidney Dis},
	volume = {1},
	year = {1982},
	month = {1982 May},
	pages = {345-52},
	abstract = {<p>Ten adult, female cynomolgus macaques were randomly assigned to two equal groups: (1) semipurified diet (SPD); and (2) SPD with 45\% ground alfalfa seed (AS). Both groups were studied at monthly intervals after 5 mo on their respective diets. Control animals had a mean hematocrit (Hct) of 43 +/- 2\%, negative antiglobulin (AG), antinuclear antibody (ANA) and LE cell tests. Mean values for C3 and C4 were 309 +/- 47 mg/dl and 35 +/- 7 mg/dl, respectively. Mean serum binding to radiolabeled double stranded deoxyribonucleic acid (dsDNA) was 1.9 +/- 0.2\%. Three of five animals fed AS developed signs of an SLE-like illness characterized by AG-positive anemia (lowest Hct 30\%), positive ANA (highest titer greater than 1:15, 360; rim pattern) and elevated anti-dsDNA binding (highest 96\%) with variable degrees of hypocomplementemia. One animal had granular deposition of immunoglobulin and complement at the dermal-epidermal junction of clinically normal skin the presence of immune complex-induced glomerulonephritis.</p>
},
	keywords = {Animals, Antibodies, Antinuclear, Biopsy, Coombs Test, Counterimmunoelectrophoresis, Diet, DNA, Female, Hematocrit, Kidney, Lupus Erythematosus, Systemic, Macaca fascicularis, Medicago sativa, Microscopy, Electron, Neutrophils},
	issn = {0272-6386},
	author = {Bardana, E J and Malinow, M R and Houghton, D C and McNulty, W P and Wuepper, K D and Parker, F and Pirofsky, B}
}
