@article {309956,
	title = {HLA and genetic susceptibility to sleepwalking.},
	journal = {Mol Psychiatry},
	volume = {8},
	year = {2003},
	month = {2003 Jan},
	pages = {114-7},
	abstract = {<p>HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0\%) were DQB1*0501 positive vs eight (13.3\%) controls (P = 0.0056; odds ratio = 3.5, 95\% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.</p>
},
	keywords = {Adolescent, Adult, Aged, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Histocompatibility Testing, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Somnambulism},
	issn = {1359-4184},
	doi = {10.1038/sj.mp.4001203},
	author = {Lecendreux, M and Bassetti, C and Dauvilliers, Y and Mayer, G and Neidhart, E and Tafti, M}
}
