@article {310008,
	title = {A beta40 is a major form of beta-amyloid in nonhuman primates.},
	journal = {Neurobiol Aging},
	volume = {17},
	year = {1996},
	month = {1996 Nov-Dec},
	pages = {903-8},
	abstract = {<p>Because aged nonhuman primates show beta-amyloid (A beta) deposition in senile plaques and blood vessels similar to that seen in human aging and AD, we used C-terminal specific antibodies to A beta40 and A beta42 to investigate A beta peptide length in the brains of 11 aged rhesus monkeys and a 59-year-old chimpanzee. In contrast to AD, where the earliest and most prominent form of A beta in senile plaques is A beta42, in the monkey, A beta40-positive plaques predominated. The ratio of A beta40:A beta42-positive plaques averaged 2.08 in the monkey, as compared to a mean ratio of 0.37 in 68 human AD subjects (p \&lt; 0.001). A beta40 was also more prominent in the chimpanzee than in humans. Possible explanations for these findings include species differences in the cleavage of A beta from the amyloid precursor protein or in the activity of a putative carboxy peptidase forming A beta40 from A beta42 in situ.</p>
},
	keywords = {Aging, Amyloid beta-Peptides, Animals, Brain, Brain Chemistry, Enzyme-Linked Immunosorbent Assay, Female, Immunohistochemistry, Macaca mulatta, Male, Pan troglodytes, Peptide Fragments, Primates},
	issn = {0197-4580},
	author = {Gearing, M and Tigges, J and Mori, H and Mirra, S S}
}
