@article {310260,
	title = {Partial hydatidiform mole in a pregnant chimpanzee (Pan troglodytes)},
	journal = {Zoo Biology},
	volume = {12},
	year = {1993},
	pages = {299{\textendash}305},
	abstract = {<p>Until now, the occurrence of hydatidiform mole in non-human primates has not been documented. This report presents a case in which a stillborn fetus, associated with a partial hydatidiform mole, was found at necropsy in the uterus of a pregnant chimpanzee (Pan troglodytes) which had suddenly died. Hydropic swelling of the chorionic villi and proliferation of trophoblastic cells were present. The trophoblast was stained enzyme-immunohistochemically with human chorionic gonadotropin (hCG) and pregnancy-specific-β1-glycoprotein (SP1). The concentrations of hCG and SP1 in maternal serum were high, 1,350 mIU/ml and 1,000 ng/ml, respectively. The distribution of DNA content of the cytotrophoblast in the molar villi shifted from diploid to an aneuploid pattern. {\textcopyright} 1993 Wiley-Liss, Inc.</p>
},
	keywords = {DNA ploidy analysis, hCG-SP1 assay, trophoblastic disease},
	issn = {1098-2361},
	doi = {10.1002/zoo.1430120307},
	url = {http://dx.doi.org/10.1002/zoo.1430120307},
	author = {Debyser, Isolde W. J. and Soma, Hiroaki and Zwart, Peernel}
}
