@article {310265,
	title = {Genome-wide detection and characterization of positive selection in human populations.},
	journal = {Nature},
	volume = {449},
	year = {2007},
	month = {2007 Oct 18},
	pages = {913-8},
	abstract = {<p>With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used {\textquoteright}long-range haplotype{\textquoteright} methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia.</p>
},
	keywords = {Antiporters, Edar Receptor, Gene Frequency, Genetics, Population, Genome, Human, Geography, Haplotypes, Humans, Models, Molecular, Polymorphism, Single Nucleotide, Protein Structure, Tertiary, Selection, Genetic},
	issn = {1476-4687},
	doi = {10.1038/nature06250},
	author = {Sabeti, Pardis C and Varilly, Patrick and Fry, Ben and Lohmueller, Jason and Hostetter, Elizabeth and Cotsapas, Chris and Xie, Xiaohui and Byrne, Elizabeth H and McCarroll, Steven A and Gaudet, Rachelle and Schaffner, Stephen F and Lander, Eric S and Frazer, Kelly A and Ballinger, Dennis G and Cox, David R and Hinds, David A and Stuve, Laura L and Gibbs, Richard A and Belmont, John W and Boudreau, Andrew and Hardenbol, Paul and Leal, Suzanne M and Pasternak, Shiran and Wheeler, David A and Willis, Thomas D and Yu, Fuli and Yang, Huanming and Zeng, Changqing and Gao, Yang and Hu, Haoran and Hu, Weitao and Li, Chaohua and Lin, Wei and Liu, Siqi and Pan, Hao and Tang, Xiaoli and Wang, Jian and Wang, Wei and Yu, Jun and Zhang, Bo and Zhang, Qingrun and Zhao, Hongbin and Zhao, Hui and Zhou, Jun and Gabriel, Stacey B and Barry, Rachel and Blumenstiel, Brendan and Camargo, Amy and Defelice, Matthew and Faggart, Maura and Goyette, Mary and Gupta, Supriya and Moore, Jamie and Nguyen, Huy and Onofrio, Robert C and Parkin, Melissa and Roy, Jessica and Stahl, Erich and Winchester, Ellen and Ziaugra, Liuda and Altshuler, David and Shen, Yan and Yao, Zhijian and Huang, Wei and Chu, Xun and He, Yungang and Jin, Li and Liu, Yangfan and Shen, Yayun and Sun, Weiwei and Wang, Haifeng and Wang, Yi and Wang, Ying and Xiong, Xiaoyan and Xu, Liang and Waye, Mary M Y and Tsui, Stephen K W and Xue, Hong and Wong, J Tze-Fei and Galver, Luana M and Fan, Jian-Bing and Gunderson, Kevin and Murray, Sarah S and Oliphant, Arnold R and Chee, Mark S and Montpetit, Alexandre and Chagnon, Fanny and Ferretti, Vincent and Leboeuf, Martin and Olivier, Jean-Fran{\c c}ois and Phillips, Michael S and Roumy, St{\'e}phanie and Sall{\'e}e, Cl{\'e}mentine and Verner, Andrei and Hudson, Thomas J and Kwok, Pui-Yan and Cai, Dongmei and Koboldt, Daniel C and Miller, Raymond D and Pawlikowska, Ludmila and Taillon-Miller, Patricia and Xiao, Ming and Tsui, Lap-Chee and Mak, William and Song, You Qiang and Tam, Paul K H and Nakamura, Yusuke and Kawaguchi, Takahisa and Kitamoto, Takuya and Morizono, Takashi and Nagashima, Atsushi and Ohnishi, Yozo and Sekine, Akihiro and Tanaka, Toshihiro and Tsunoda, Tatsuhiko and Deloukas, Panos and Bird, Christine P and Delgado, Marcos and Dermitzakis, Emmanouil T and Gwilliam, Rhian and Hunt, Sarah and Morrison, Jonathan and Powell, Don and Stranger, Barbara E and Whittaker, Pamela and Bentley, David R and Daly, Mark J and de Bakker, Paul I W and Barrett, Jeff and Chretien, Yves R and Maller, Julian and McCarroll, Steve and Patterson, Nick and Pe{\textquoteright}er, Itsik and Price, Alkes and Purcell, Shaun and Richter, Daniel J and Sabeti, Pardis and Saxena, Richa and Schaffner, Stephen F and Sham, Pak C and Varilly, Patrick and Altshuler, David and Stein, Lincoln D and Krishnan, Lalitha and Smith, Albert Vernon and Tello-Ruiz, Marcela K and Thorisson, Gudmundur A and Chakravarti, Aravinda and Chen, Peter E and Cutler, David J and Kashuk, Carl S and Lin, Shin and Abecasis, Gon{\c c}alo R and Guan, Weihua and Li, Yun and Munro, Heather M and Qin, Zhaohui Steve and Thomas, Daryl J and McVean, Gilean and Auton, Adam and Bottolo, Leonardo and Cardin, Niall and Eyheramendy, Susana and Freeman, Colin and Marchini, Jonathan and Myers, Simon and Spencer, Chris and Stephens, Matthew and Donnelly, Peter and Cardon, Lon R and Clarke, Geraldine and Evans, David M and Morris, Andrew P and Weir, Bruce S and Tsunoda, Tatsuhiko and Johnson, Todd A and Mullikin, James C and Sherry, Stephen T and Feolo, Michael and Skol, Andrew and Zhang, Houcan and Zeng, Changqing and Zhao, Hui and Matsuda, Ichiro and Fukushima, Yoshimitsu and Macer, Darryl R and Suda, Eiko and Rotimi, Charles N and Adebamowo, Clement A and Ajayi, Ike and Aniagwu, Toyin and Marshall, Patricia A and Nkwodimmah, Chibuzor and Royal, Charmaine D M and Leppert, Mark F and Dixon, Missy and Peiffer, Andy and Qiu, Renzong and Kent, Alastair and Kato, Kazuto and Niikawa, Norio and Adewole, Isaac F and Knoppers, Bartha M and Foster, Morris W and Clayton, Ellen Wright and Watkin, Jessica and Gibbs, Richard A and Belmont, John W and Muzny, Donna and Nazareth, Lynne and Sodergren, Erica and Weinstock, George M and Wheeler, David A and Yakub, Imtaz and Gabriel, Stacey B and Onofrio, Robert C and Richter, Daniel J and Ziaugra, Liuda and Birren, Bruce W and Daly, Mark J and Altshuler, David and Wilson, Richard K and Fulton, Lucinda L and Rogers, Jane and Burton, John and Carter, Nigel P and Clee, Christopher M and Griffiths, Mark and Jones, Matthew C and McLay, Kirsten and Plumb, Robert W and Ross, Mark T and Sims, Sarah K and Willey, David L and Chen, Zhu and Han, Hua and Kang, Le and Godbout, Martin and Wallenburg, John C and L{\textquoteright}Archev{\^e}que, Paul and Bellemare, Guy and Saeki, Koji and Wang, Hongguang and An, Daochang and Fu, Hongbo and Li, Qing and Wang, Zhen and Wang, Renwu and Holden, Arthur L and Brooks, Lisa D and McEwen, Jean E and Guyer, Mark S and Wang, Vivian Ota and Peterson, Jane L and Shi, Michael and Spiegel, Jack and Sung, Lawrence M and Zacharia, Lynn F and Collins, Francis S and Kennedy, Karen and Jamieson, Ruth and Stewart, John}
}
