@article {310449,
	title = {Teratological and toxicological studies of alkaloidal and phenolic compounds from Solanum Tuberosum },
	volume = {36},
	year = {1976},
	month = {01/1976},
	pages = {227 - 237},
	abstract = {<p>A comparative study of acute and chronic ip administration was made in pregnant and nonpregnant (female) rats of alkaloidal (α-chaconine, α-solanine total glycoalkaloidal extract (TGA-extract)) and phenolic compounds (chlorogenic and caffeic acid) from Solanum Tuberosum L. The acute LD50 and 95\% confidence limits for α-chaconine, α-solanine, and the TGA-extract were 84 (65.6{\textendash}107.5), 67 (52.3{\textendash}85.7), and 60 mg/kg (35.7{\textendash}100.8). There was no significant difference in their potency at the 95\% confidence limit. Chronic adminstration of α-chaconine, α-solanine, and the TGA-extract to nonpregnant rats for 2 days (40 mg/kg/day) and 8 days (20 mg/kg/day) resulted in 40 and 42\% mortality, respectively. Eight daily injections of α-chaconine (5{\textendash}20 mg/kg) on Days 5{\textendash}12 or 2 (40 mg/kg) on Days 5 and 6 to pregnant rats resulted in maternal (40{\textendash}66\%) and fetal death (15{\textendash}100\%), whereas α-solanine and the TGA-extract administered similarly were lethal only to the fetus (17{\textendash}86\%). Eight daily injections of chlorogenic (5{\textendash}500 mg/kg) and caffeic acid (40{\textendash}187.5 mg/kg) on Days 5{\textendash}12 of gestation did not cause maternal or fetal lethality. None of the compounds tested produced neural tube defects, but a few 21-day-old fetuses had rib abnormalities.</p>
},
	isbn = {0041-008X},
	url = {http://www.sciencedirect.com/science/article/pii/0041008X76900028},
	author = {Chaube, S. and Swinyard, C. A.}
}
