@article {310541,
	title = {Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection.},
	journal = {Scand J Immunol},
	volume = {76},
	year = {2012},
	month = {10/2012},
	pages = {440-7},
	abstract = {<p>The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0\% versus 18.2\%, P=0.0016, OR=0.23, CI 95\% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2\% versus 15.3\%, P=0.0032; OR = 0.24, CI 95\% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with \&lt;20 years of infection (38.4\% versus 9.1\%, P = 0.002, OR = 6.25, CI 95\%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.</p>
},
	keywords = {Adult, Alleles, Brazil, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Hepatitis C, Chronic, HLA-C Antigens, HLA-DRB1 Chains, Humans, Immunophenotyping, Liver, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Time Factors},
	issn = {1365-3083},
	doi = {10.1111/j.1365-3083.2012.02755.x},
	author = {Marangon, A V and Silva, G F and de Moraes, C F V and Grotto, R M T and Pardini, M I M C and de Pauli, D S and Visentainer, J E L and Sell, A M and Moliterno, R A}
}
