@article {310921,
	title = {A fine-scale map of recombination rates and hotspots across the human genome.},
	journal = {Science},
	volume = {310},
	year = {2005},
	month = {10/2005},
	pages = {321-4},
	abstract = {<p>Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.</p>
},
	keywords = {Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Evolution, Molecular, Female, Genome, Human, Humans, Male, Models, Genetic, Polymorphism, Single Nucleotide, Recombination, Genetic},
	issn = {1095-9203},
	doi = {10.1126/science.1117196},
	author = {Myers, Simon and Bottolo, Leonardo and Freeman, Colin and McVean, Gil and Donnelly, Peter}
}
