@article {310922,
	title = {Comparison of fine-scale recombination rates in humans and chimpanzees.},
	journal = {Science},
	volume = {308},
	year = {2005},
	month = {04/2005},
	pages = {107-11},
	abstract = {<p>We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99\% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.</p>
},
	keywords = {Alleles, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Chromosomes, Mammalian, Evolution, Molecular, Genome, Genome, Human, Genotype, Globins, Haplotypes, HLA Antigens, Humans, Linkage Disequilibrium, Markov Chains, Monte Carlo Method, Pan troglodytes, Polymorphism, Single Nucleotide, Recombination, Genetic, Sequence Homology, Nucleic Acid},
	issn = {1095-9203},
	doi = {10.1126/science.1105322},
	author = {Winckler, W. and Myers, S. R. and Richter, D. J. and Onofrio, R. C. and McDonald, G. J. and Bontrop, R. E. and McVean, G. A. T. and Gabriel, S. B. and Reich, D. and Donnelly, P. and Altshuler, D.}
}
