@article {311046,
	title = {Colocalization of parvalbumin and calbindin D-28k in neurons including chandelier cells of the human temporal neocortex.},
	journal = {J Chem Neuroanat},
	volume = {12},
	year = {1997},
	month = {1997 Mar},
	pages = {165-73},
	abstract = {<p>Chandelier cells are cortical GABAergic interneurons with a unique synaptic specificity enabling them to exert a strong inhibitory influence on pyramidal cells. By using immunocytochemistry for the calcium-binding protein calbindin D-28k in the human temporal neocortex, we have found numerous immunoreactive processes that were identified as chandelier cell axon terminals. This was a striking find since in previous immunocytochemical studies of the primate neocortex, chandelier cell axon terminals had been shown to be immunoreactive for another calcium-binding protein, parvalbumin, and colocalization studies indicate that parvalbumin and calbindin are present in almost completely separate neuronal populations. Here, we present double-label immunofluorescence experiments showing that parvalbumin and calbindin immunoreactivities are colocalized in certain neurons that include a subpopulation of chandelier cells whose cell bodies are located mainly in layers V and VI of the human temporal neocortex. The results suggest a selective laminar distribution of neurochemical subtypes of chandelier cells which is a peculiar feature of the organization of the human neocortex.</p>
},
	keywords = {Adolescent, Adult, Calbindins, Fluorescent Antibody Technique, Direct, Humans, Immunohistochemistry, Neurons, Parvalbumins, Presynaptic Terminals, S100 Calcium Binding Protein G, Temporal Lobe},
	issn = {0891-0618},
	author = {del R{\'\i}o, M R and DeFelipe, J}
}
