@article {311062,
	title = {The genetic and evolutionary balances in human NK cell receptor diversity.},
	journal = {Semin Immunol},
	volume = {20},
	year = {2008},
	month = {2008 Dec},
	pages = {311-6},
	abstract = {<p>In primates and cattle two ancient killer-cell immunoglobulin-like receptor (KIR) lineages independently evolved to become diverse NK cell receptors. In mice, KIR genes were sidelined to the X chromosome, a possible consequence of pathogen-mediated selection on the receptor for IgA-Fc. In humans, KIR uniquely form two omnipresent haplotype groups (A and B), postulated here to play complementary and necessary roles in immune defense and reproduction. The basis of KIR3DL1/S1 polymorphism is three ancient lineages maintained by long-term balancing selection and present in all human populations. Conserved and variable NK cell receptors produce structurally diverse NK cell receptor repertoires within a defined range of missing-self-response.</p>
},
	keywords = {Animals, Antigens, CD, Evolution, Molecular, Genetic Variation, Humans, Killer Cells, Natural, Receptors, Fc, Receptors, KIR, Receptors, KIR3DL1, Receptors, Natural Killer Cell, Reproduction},
	issn = {1044-5323},
	doi = {10.1016/j.smim.2008.10.002},
	author = {Parham, Peter}
}
