@article {313216,
	title = {Ancient recombination events between human herpes simplex viruses},
	journal = {Molecular Biology and Evolution},
	year = {2017},
	month = {03/28/ 2017},
	abstract = {<p><span style="color: rgb(42, 42, 42); font-family: Merriweather, serif; font-size: 16px; background-color: rgb(239, 242, 247);">Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are seen as close relatives but also unambiguously considered as evolutionary independent units. Here, we sequenced the genomes of 18 HSV-2 isolates characterized by divergent UL30 gene sequences to further elucidate the evolutionary history of this virus. Surprisingly, genome-wide recombination analyses showed that all HSV-2 genomes sequenced to date contain HSV-1 fragments. Using phylogenomic analyses, we could also show that two main HSV-2 lineages exist. One lineage is mostly restricted to sub-Saharan Africa while the other has reached a global distribution. Interestingly, only the worldwide lineage is characterized by ancient recombination events with HSV-1. Our findings highlight the complexity of HSV-2 evolution, a virus of putative zoonotic origin which later recombined with its human-adapted relative. They also suggest that co-infections with HSV-1 and 2 may have genomic and potentially functional consequences and should therefore be monitored more closely.</span></p>
},
	doi = {https://doi.org/10.1093/molbev/msx113},
	url = {https://academic.oup.com/mbe/article/3078671/Ancient-recombination-events-between-human-herpes?searchresult=1},
	author = {Burrel, Sonia and Boutolleau,  David and Ryu, Diane and Agut, Henri and Merkel, Kevin and Leendertz, Fabian H. and Calvignac-Spencer, S{\'e}bastien}
}
