@article {315210, title = {A high-coverage Neandertal genome from Vindija Cave in Croatia}, journal = {Science}, year = {2017}, month = {2017/10/05}, abstract = {

To date the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50 thousand years ago from Vindija Cave, Croatia to ~30-fold genomic coverage. She carried 1.6 differences per ten thousand base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10-20\% more Neandertal DNA to be identified in present-day humans, including variants involved in LDL cholesterol levels, schizophrenia and other diseases.

}, doi = {10.1126/science.aao1887}, url = {http://science.sciencemag.org/content/early/2017/10/04/science.aao1887}, author = {Pr{\"u}fer, Kay and de Filippo, Cesare and Grote, Steffi and Mafessoni, Fabrizio and Korlevi{\'c}, Petra and Hajdinjak, Mateja and Vernot, Benjamin and Skov, Laurits and Hsieh, Pinghsun and Peyr{\'e}gne, St{\'e}phane and Reher, David and Hopfe, Charlotte and Nagel, Sarah and Maricic, Tomislav and Fu, Qiaomei and Theunert, Christoph and Rogers, Rebekah and Skoglund, Pontus and Chintalapati, Manjusha and Dannemann, Michael and Nelson, Bradley J. and Key, Felix M. and Rudan, Pavao and Kucan, Zeljko and Gusic, Ivan and Golovanova, Liubov V. and Doronichev, Vladimir B. and Patterson, Nick and Reich, David and Eichler, Evan E. and Slatkin, Montgomery and Schierup, Mikkel H. and Andr{\'e}s, Aida and Kelso, Janet and Meyer, Matthias and P{\"a}{\"a}bo, Svante} }