@article {315679,
	title = {Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders.},
	journal = {Elife},
	volume = {6},
	year = {2017},
	month = {10/2017},
	pages = {e26724},
	abstract = {<p>A leading theory holds that neurodevelopmental brain disorders arise from imbalances in excitatory and inhibitory (E/I) brain circuitry. However, it is unclear whether this one-dimensional model is rich enough to capture the multiple neural circuit alterations underlying brain disorders. Here, we combined computational simulations with analysis of in vivo two-photon Ca2+ imaging data from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance theory. We found that: (1) The E/I imbalance model cannot account for joint alterations in the observed neural firing rates and correlations; (2) Neural circuit function is vastly more sensitive to changes in some cellular components over others; (3) The direction of circuit alterations in Fmr1 KO mice changes across development. These findings suggest that the basic E/I imbalance model should be updated to higher dimensional models that can better capture the multidimensional computational functions of neural circuits.</p>
},
	keywords = {E/I balance; Fragile-X Syndrome; computational modelling; human biology; medicine; mouse; neural circuits; neuroscience},
	isbn = {2050-084X},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/29019321},
	author = {O{\textquoteright}Donnell, C and Gon{\c c}alves, JT and Portera-Cailliau, C and Sejnowski, TJ}
}
