@article {316357,
	title = {Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.},
	journal = {Nature},
	volume = {553},
	number = {7686},
	year = {2018},
	month = {01/},
	pages = {77-81},
	abstract = {<p>In contrast to infections with human immunodeficiency virus (HIV) in humans and simian immunodeficiency virus (SIV) in macaques, SIV infection of a natural host, sooty mangabeys (Cercocebus atys), is non-pathogenic despite high viraemia. Here we sequenced and assembled the genome of a captive sooty mangabey. We conducted genome-wide comparative analyses of transcript assemblies from C. atys and AIDS-susceptible species, such as humans and macaques, to identify candidates for host genetic factors that influence susceptibility. We identified several immune-related genes in the genome of C. atys that show substantial sequence divergence from macaques or humans. One of these sequence divergences, a C-terminal frameshift in the toll-like receptor-4 (TLR4) gene of C. atys, is associated with a blunted in vitro response to TLR-4 ligands. In addition, we found a major structural change in exons 3-4 of the immune-regulatory protein intercellular adhesion molecule 2 (ICAM-2); expression of this variant leads to reduced cell surface expression of ICAM-2. These data provide a resource for comparative genomic studies of HIV and/or SIV pathogenesis and may help to elucidate the mechanisms by which SIV-infected sooty mangabeys avoid AIDS.</p>
},
	isbn = {0028-0836},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/29300007},
	author = {Palesch, D and Bosinger, SE and Tharp, GK and Vanderford, TH and Paiardini, M and Chahroudi, A and Johnson, ZP and Kirchhoff, F and Hahn, BH and Norgren, RB and Patel, NB and Sodora, DL and Dawoud, RA and Stewart, CB and Seepo, SM and Harris, RA and Liu, Y and Raveendran, M and Han, Y and English, A and Thomas, GWC and Hahn, MW and Pipes, L and Mason, CE and Muzny, DM and Gibbs, RA and Sauter, D and Worley, K and Rogers, J and Silvestri, G}
}
