@article {318321,
	title = {Species-specific maturation profiles of human, chimpanzee and bonobo neural cells},
	journal = {eLife},
	volume = {8},
	year = {2019},
	month = {2019/02/07},
	pages = {e37527},
	abstract = {<p>Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex. Our results show differential migration patterns in human neural progenitor cells compared to those of chimpanzees and bonobos both in vitro and in vivo, suggesting heterochronic changes in human neurons. The strategy proposed here lays the groundwork for further comparative analyses between humans and NHPs and opens new avenues for understanding the differences in the neural underpinnings of cognition and neurological disease susceptibility between species.</p>
},
	keywords = {Chimpanzee, Evolution, neurodevelopment, neuronal function, neuroprogenitor migration, non human primate},
	isbn = {2050-084X},
	doi = {https://doi.org/10.7554/eLife.37527   },
	url = {https://elifesciences.org/articles/37527},
	author = {Marchetto, MC and Hrvoj-Mihic, B and Kerman, BE and Yu, DX and Vadodaria, KC and Linker, SB and Narvaiza, I and Santos, R and Denli, AM and Mendes, APD and Oefner, R and Cook, J and McHenry, L and Grasmick, JM and Heard, K and Fredlender, C and Randolph-Moore, L and Kshirsagar, R and Xenitopoulos, R and Chou, G and Hah, N and Muotri, AR and Padmanabhan, K and Semendeferi, K and Gage, FH},
	editor = {Zoghbi, HY and Arlotta, P}
}
