@article {318325,
	title = {Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.},
	journal = {Genes (Basel)},
	volume = {9},
	year = {2018},
	month = {09/2018},
	abstract = {<p>The derived human alcohol dehydrogenase allele of the polymorphism (rs1229984) has been identified as one component of an East Asian specific core haplotype that underwent recent positive selection. Our study has been extended to Southwest Asia and additional markers in East Asia. values (Sewall Wright{\textquoteright}s fixation index) and long-range haplotype analyses identify a strong signature of selection not only in East Asian but also in Southwest Asian populations. However, except for the allele, different core haplotypes occur in Southwest Asia compared to East Asia and the extended haplotypes also differ. Thus, the allele, as part of a core haplotype of 10 kb, has undergone recent rapid increases in frequency independently in the two regions after divergence of the respective populations. Emergence of agriculture may be the common factor underlying the evident selection.</p>
},
	issn = {2073-4425},
	doi = {10.3390/genes9090452},
	url = {https://www.mdpi.com/2073-4425/9/9/452},
	author = {Gu, Sheng and Li, Hui and Pakstis, Andrew J and Speed, William C and Gurwitz, David and Kidd, Judith R and Kidd, Kenneth K}
}
