@article {318881,
	title = {A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex},
	journal = {Development},
	year = {2018},
	month = {01/2018},
	pages = {dev.169276},
	abstract = {<p>A specific subpopulation of neural progenitor cells, the basal radial glia cells (bRGCs) of the outer subventricular zone (OSVZ), are thought to have a key role in the evolutionary expansion of the mammalian neocortex. In the developing lissencephalic mouse neocortex, bRGCs exist at low abundance and show significant molecular differences from bRGCs in developing gyrencephalic species. Here, we demonstrate that the developing mouse medial neocortex (medNcx), in contrast to the canonically studied latNcx (latNcx), exhibits an OSVZ and an abundance of bRGCs similar to that in developing gyrencephalic neocortex. Unlike bRGCs in developing mouse latNcx, the bRGCs in medNcx exhibit human bRGC-like gene expression, including expression of Hopx, a human bRGC marker. Disruption of Hopx expression in mouse embryonic medNcx and forced Hopx expression in mouse embryonic latNcx demonstrate that Hopx is required and sufficient, respectively, for a bRGC abundance as found in developing gyrencephalic neocortex. Taken together, our data identify a novel bRGC subpopulation in developing mouse medNcx that is highly related to bRGCs of developing gyrencephalic neocortex.</p>
},
	doi = {10.1242/dev.169276},
	url = {http://dev.biologists.org/content/early/2018/09/26/dev.169276.abstract},
	author = {Vaid, S and Camp, JG and Hersemann, L and Oegema, CE and Heninger, AK and Winkler, S and Brandl, H and Sarov, M and Treutlein, B and Huttner, WB and Namba, T}
}
